This is 1.4 per cent of the total land area of Ghana. Addressing the issue will require an integrated public health strategy and rethinking of the implementation gaps in the current HBV infection control program. We therefore conducted this study to summarize and update the available information on HBV infection burden (prevalence) in Ghana from 2015–2019.We systematically searched PubMed, Embase, ScienceDirect, and Google Scholar to retrieve primary studies published in peer-reviewed journals from November 2015 to September 2019, assessing the prevalence of HBV among the Ghanaian populace. Due to the limited number of studies included in each meta-analysis, we were not able to explore the potential of publication bias [This systematic review and meta-analysis indicated that the prevalence of HBV infection between 2015 and 2019 in Ghana was 0.55%, 14.30%, and 8.36% among pre-school children, adolescents, and adults, respectively. The Electoral Commission (EC) says the majority of Ghanaians who used the guarantor system to register for the new voters’ ID card, did so in the Bono East, Bono and Ahafo regions.The Chairperson of the Commission, Jean Mensa at a press conference in Accra on Wednesday said out of the about 16 million persons who registered for the card, 37.99% of them used guarantors to authenticate their Ghanaian identity.The guarantor system is for persons who did not have other requirements, like the Ghana Card and the passport to be able to register for the new ID card.According to Jean Mensa, 58.5% of those who registered in the Bono East Region used the guarantor system, the highest number across all regions.The Bono East Region was followed by the Bono and Ahafo regions which had 57.7% each of its registered population doing so through the guarantor system.“Regarding the use of the guarantor system, the Bono East Region recorded the highest use of the guarantor system with 58.5% registering through guarantors. The government and its partner agencies, therefore, need to explore the possibility of a free HBV vaccination policy with the goal of eliminating this disease burden.We wish to thank the staff of the epidemiology and health statistics department for their technical support. In 2019, the unemployment rate in Ghana was at approximately 4.33 percent of the total labor force. A previous study revealed poor knowledge about HBV transmission among barbers in an urban area in Ghana [HBV prevalence among patients with HIV was determined to be 8.92%, although this rate is lower than the 13.60% reported in a previous systematic review by Agyeman and Ofori-Asenso in 2016 [The WHO’s target to eliminate HBV by the year 2030 seems unachievable in Ghana if the trends in the healthcare system are not realigned towards universal care in the face of this high prevalence. The HBV prevalence ranged from 2.45% in the Northern region to 16.70% in the Western region. Click through the PLOS taxonomy to find articles in your field.For more information about PLOS Subject Areas, click Transfusion safety of blood and blood products in Ghana should be a major concern as about one in every ten blood donors is infected with HBV. The review considered the regional distribution of studies based on the ten old regions and combined the six recently established regions to their mother regions. There was a significantly low prevalence among pre-school children and a decline in the adult population in Ghana. Across the country, the highest HBV infection prevalence rates were recorded in the age group of 20–40 years. However, no such situation arose.Using a predesigned data extraction form, JA and HW independently extracted the following data from each study: study characteristics, including the name of the primary author, publication year, study design, sample size, methods of testing HBV, and prevalence of HBV. The burden of chronic HBV infection is also unevenly distributed among the various subpopulations in the adult group and remains high per the WHO’s level of categorization. A national survey that covers all regions in the country to estimate the actual burden of the disease in Ghana is needed.The pooled HBV prevalence was very low (0.55%) among pre-school children. PLOS is a nonprofit 501(c)(3) corporation, #C2354500, based in San Francisco, California, US